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C9orf7 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UGQ2 |
| Other Accession | D4A9I3, Q8BG21, NP_060056.1, NP_001129247.1 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 18470 Da |
| Antigen Region | 123-151 aa |
| Gene ID | 11094 |
|---|---|
| Other Names | Calcium channel flower homolog, Calcium channel flower domain-containing protein 1, CACFD1, C9orf7 |
| Target/Specificity | This C9orf7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-151 amino acids from the C-terminal region of human C9orf7. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | C9orf7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CACFD1 |
|---|---|
| Synonyms | C9orf7 |
| Function | Transmembrane protein which mediates synaptic endocytosis and fitness-based cell culling (PubMed:31341286, PubMed:37348560). In response to different stimulus strengths, controls two major modes of synaptic vesicle (SV) retrieval in hippocampal neurons; Clathrin- mediated endocytosis (CME) in response to mild stimulation and activity-dependent bulk endocytosis (ADBE) in response to strong stimulation (By similarity). In cytotoxic T-lymphoocytes (CTLs) facilitates calcium-dependent endocytosis of cytotoxic granules at the immuno synapse (By similarity). Different isoforms work as fitness fingerprints in 'loser' and 'winner' cells and thereby mediate win/lose decisions as part of the cell competition process (PubMed:31341286). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:D4A9I3}. Golgi apparatus {ECO:0000250|UniProtKB:D4A9I3}. Vesicle {ECO:0000250|UniProtKB:Q8BG21} Note=In cytotoxic T-lymphoocytes, localizes to intracellular vesicles that move to the immuno synapse (By similarity). Enriched in synaptic vesicles at the presynpatic vesicles (By similarity). Detected in the Golgi apparatus of cultured hippocampal neurons (By similarity) {ECO:0000250|UniProtKB:D4A9I3, ECO:0000250|UniProtKB:Q8BG21} [Isoform 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Detected in skin cells at low levels of expression (at protein level). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
C9orf7 belongs to the calcium channel flower family.
REFERENCES
Yao, C.K., et al. Cell 138(5):947-960(2009)
Yuan, X., et al. Am. J. Hum. Genet. 83(4):520-528(2008)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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