癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HLF Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q16534 |
| Other Accession | Q64709, Q8BW74, NP_002117.1 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 33199 Da |
| Antigen Region | 204-232 aa |
| Gene ID | 3131 |
|---|---|
| Other Names | Hepatic leukemia factor, HLF |
| Target/Specificity | This HLF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-232 amino acids from the C-terminal region of human HLF. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HLF Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | HLF {ECO:0000303|PubMed:1516826, ECO:0000312|HGNC:HGNC:4977} |
|---|---|
| Function | Transcription factor which selectively binds with high affinity to the consensus sequence 5'-GTTACGTAAT-3' and to closely related sites (PubMed:8065331, PubMed:8164688, PubMed:8639829). Has transcriptional activator activity (PubMed:10073576, PubMed:8065331, PubMed:8164688, PubMed:8639829). Also has transcriptional repressor activity (By similarity). Binds to multiple sites in the promoter regions of coagulation factors F8 and F9 and activates transcription; transactivation activity is enhanced by formation of a heterodimer with DBP (PubMed:10073576). Binds to the promoter region of IRF2 and activates transcription (By similarity). Maintains quiescence of hematopoietic stem cells under steady-state conditions and protects the stem cell pool from toxic insults (By similarity). Regulates the tissue residency and proinflammatory function of CD4+ tissue-resident memory T (TRM) cells (By similarity). Down-regulates the expression of genes involved in promoting tissue egress of CD4+ TRM cells including S1PR1, KLF2 and TCF7 while up-regulating expression of tissue retention molecules such as CD69 (By similarity). Also up-regulates BHLHE40 expression, promoting proinflammatory cytokine production (By similarity). |
| Cellular Location | Nucleus. |
| Tissue Location | Highly expressed in liver; lower levels in lung and kidney |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
REFERENCES
Hirose, K., et al. Blood 116(6):962-970(2010)
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Otto, T., et al. Endocrinology 149(5):2241-2250(2008)
Inukai, T., et al. Leukemia 21(2):288-296(2007)
He, J., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22(5):551-553(2005)
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