癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Mouse Vrk2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8BN21 |
| Other Accession | NP_081536.2 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 58119 Da |
| Antigen Region | 354-381 aa |
| Gene ID | 69922 |
|---|---|
| Other Names | Serine/threonine-protein kinase VRK2, Vaccinia-related kinase 2, Vrk2 |
| Target/Specificity | This Mouse Vrk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 354-381 amino acids from the C-terminal region of mouse Vrk2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Vrk2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Vrk2 |
|---|---|
| Function | Serine/threonine kinase that regulates several signal transduction pathways (PubMed:14645249). Modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen- activated protein kinase (MAPK) complexes (By similarity). Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription (By similarity). Phosphorylates histone H3 (By similarity). Phosphorylates 'Thr-18' of p53/TP53, and thereby increases its stability and activity (By similarity). Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain- containing proteins (By similarity). Down-regulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1 (By similarity). Blocks the phosphorylation of ERK in response to ERBB2 and HRAS (By similarity). May also phosphorylate MAPK8IP1 (By similarity). Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant (By similarity). |
| Cellular Location | Cytoplasm. Endoplasmic reticulum membrane; Single- pass type IV membrane protein. Mitochondrion membrane {ECO:0000250|UniProtKB:Q86Y07}; Single-pass type IV membrane protein. Nucleus envelope |
| Tissue Location | Expressed in liver, kidney and muscle. Weakly expressed in thymus, bone marrow and spleen |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Probable serine/threonine kinase (By similarity).
REFERENCES
Bailey, P.J., et al. Exp. Cell Res. 312(16):3108-3119(2006)
Wang, S., et al. PLoS Genet. 2 (2), E15 (2006) :
Nichols, R.J., et al. J. Biol. Chem. 279(9):7934-7946(2004)
Vega, F.M., et al. FEBS Lett. 544 (1-3), 176-180 (2003) :
Agoulnik, A.I., et al. Hum. Mol. Genet. 11(24):3047-3053(2002)
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¥ 1,250.00
Cat# AP17443b
