癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ARID5B Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q14865 |
| Other Accession | Q8BM75, Q5ZJ69, E1BLP6, NP_115575.1 |
| Reactivity | Human |
| Predicted | Bovine, Chicken, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 132375 Da |
| Antigen Region | 389-418 aa |
| Gene ID | 84159 |
|---|---|
| Other Names | AT-rich interactive domain-containing protein 5B, ARID domain-containing protein 5B, MRF1-like protein, Modulator recognition factor 2, MRF-2, ARID5B, DESRT, MRF2 |
| Target/Specificity | This ARID5B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-418 amino acids from the Central region of human ARID5B. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ARID5B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARID5B |
|---|---|
| Synonyms | DESRT, MRF2 |
| Function | Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355}. |
| Tissue Location | Widely expressed, including in liver (at protein level). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
DNA-binding protein that binds to the 5'-AATA[CT]-3' core sequence. Probably acts as a transcription regulator. Represses the cytomegalovirus enhancer. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may act as a regulator of smooth muscle cell differentiation and proliferation. May be involved in lipid stores.
REFERENCES
Healy, J., et al. Haematologica 95(9):1608-1611(2010)
Yang, W., et al. Leukemia 24(4):894-896(2010)
Prasad, R.B., et al. Blood 115(9):1765-1767(2010)
Papaemmanuil, E., et al. Nat. Genet. 41(9):1006-1010(2009)
Trevino, L.R., et al. Nat. Genet. 41(9):1001-1005(2009)
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