癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GLDN Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q6ZMI3 |
| Other Accession | NP_861454.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 58957 Da |
| Antigen Region | 271-299 aa |
| Gene ID | 342035 |
|---|---|
| Other Names | Gliomedin, GLDN, COLM |
| Target/Specificity | This GLDN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-299 amino acids from the Central region of human GLDN. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GLDN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GLDN |
|---|---|
| Synonyms | COLM |
| Function | Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q80WL1, ECO:0000269|PubMed:27616481}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q80WL1}. Cell projection, axon {ECO:0000250|UniProtKB:Q80WL1}. Note=Detected at the nodes of Ranvier Detected at immature heminodes. {ECO:0000250|UniProtKB:Q80WL1} |
| Tissue Location | Specifically expressed in spinal cord, brain, placenta and sciatic nerve. More abundant in peripheral than central nervous system. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GLDN plays a role in the formation of the nodes of Ranvier along myelinated axons. Probable NRCAM and NFASC/neurofascin ligand which may provide a glial positional clue required for the proper molecular assembly of the nodes of Ranvier (By similarity).
REFERENCES
Eshed, Y., et al. Neuron 47(2):215-229(2005)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Graveel, C.R., et al. Oncogene 22(11):1730-1736(2003)
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