癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PGM5 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q15124 |
| Other Accession | NP_068800.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 62225 Da |
| Antigen Region | 404-430 aa |
| Gene ID | 5239 |
|---|---|
| Other Names | Phosphoglucomutase-like protein 5, Aciculin, Phosphoglucomutase-related protein, PGM-RP, PGM5, PGMRP |
| Target/Specificity | This PGM5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 404-430 amino acids from the C-terminal region of human PGM5. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PGM5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PGM5 (HGNC:8908) |
|---|---|
| Synonyms | PGMRP |
| Function | Component of adherens-type cell-cell and cell-matrix junctions (PubMed:8175905). Has no phosphoglucomutase activity in vitro (PubMed:8175905). |
| Cellular Location | Cell junction, adherens junction. Cytoplasm, cytoskeleton. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q8BZF8}. Note=Concentrated in focal contacts at the ends of actin bundles, and associated with actin filaments |
| Tissue Location | Detected in smooth and cardiac muscle at high levels and in skeletal muscle at low level. Present in other tissues due to vascular or other smooth muscle component. Low levels are present in liver, kidney, skin and brain (at protein level) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Phosphoglucomutases (EC 5.2.2.2.), such as PGM5, are phosphotransferases involved in interconversion of glucose-1-phosphate and glucose-6-phosphate. PGM activity is essential in formation of carbohydrates from glucose-6-phosphate and in formation of glucose-6-phosphate from galactose and glycogen (Edwards et al., 1995 [PubMed 8586438]).
REFERENCES
Wakayama, Y., et al. Acta Neuropathol. 99(6):654-662(2000)
Moiseeva, E.P., et al. Eur. J. Biochem. 248(3):634-643(1997)
Moiseeva, E.P., et al. Eur. J. Biochem. 235 (1-2), 103-113 (1996) :
Edwards, Y.H., et al. Genomics 30(2):350-353(1995)
Belkin, A.M., et al. Exp. Cell Res. 221(1):132-140(1995)
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