癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ERAL1 Antibody (Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O75616 |
| Other Accession | NP_005693.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Bovine, Canine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 48350 Da |
| Antigen Region | 152-180 aa |
| Gene ID | 26284 |
|---|---|
| Other Names | GTPase Era, mitochondrial, H-ERA, hERA, Conserved ERA-like GTPase, CEGA, ERA-W, ERA-like protein 1, ERAL1, HERA |
| Target/Specificity | This ERAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152-180 amino acids from the Central region of human ERAL1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ERAL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ERAL1 |
|---|---|
| Synonyms | HERA |
| Function | Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly. |
| Cellular Location | Mitochondrion matrix. Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes on the matrix side on the mitochondrial inner membrane |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Era is an essential GTPase that is required for proper cell cycle progression and cell division in E. coli. Human homologues have been isolated which have been designated ERAL1A and ERAL1B.
REFERENCES
Dennerlein, S., et al. Biochem. J. 430(3):551-558(2010)
Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :
Akiyama, T., et al. Genes Cells 6(11):987-1001(2001)
Britton, R.A., et al. Genomics 67(1):78-82(2000)
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