癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CRISP1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | P54107 |
| Other Accession | NP_001122.2, NP_733758.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28481 Da |
| Antigen Region | 162-191 aa |
| Gene ID | 167 |
|---|---|
| Other Names | Cysteine-rich secretory protein 1, CRISP-1, AEG-like protein, ARP, Acidic epididymal glycoprotein homolog, CRISP1, AEGL1 |
| Target/Specificity | This CRISP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-191 amino acids from the C-terminal region of human CRISP1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CRISP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CRISP1 |
|---|---|
| Synonyms | AEGL1 |
| Function | May have a role in sperm-egg fusion and maturation. |
| Cellular Location | Note=Located in the lumen and epithelium of distal ductus efferentes and epididymal ducts, and on the postacrosomal region of the sperm head |
| Tissue Location | Caput, corpus, and cauda regions of the epididymis, the ductus deferens, sperm and seminal plasma |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is a member of the cysteine-rich secretory protein (CRISP) family. This protein is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head where it plays a role at fertilization in sperm-egg fusion through complementary sites localized on the egg surface. Two isoforms are encoded by transcript variants of this gene.
REFERENCES
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Evans, J.P. Hum. Reprod. Update 8(4):297-311(2002)
Cuasnicu, P.S., et al. Arch. Med. Res. 32(6):614-618(2001)
Cohen, D.J., et al. Biol. Reprod. 65(4):1000-1005(2001)
Kirchhoff, C. Rev. Reprod. 3(2):86-95(1998)
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