癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TOX4 Antibody (N-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O94842 |
| Other Accession | NP_055643.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Rabbit, Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 66195 Da |
| Antigen Region | 172-199 aa |
| Gene ID | 9878 |
|---|---|
| Other Names | TOX high mobility group box family member 4, Epidermal Langerhans cell protein LCP1, TOX4, C14orf92, KIAA0737 |
| Target/Specificity | This TOX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-199 amino acids from the N-terminal region of human TOX4. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TOX4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TOX4 {ECO:0000303|PubMed:34914893, ECO:0000312|HGNC:HGNC:20161} |
|---|---|
| Function | Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate (By similarity). In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1 (By similarity). This regulation is independent of the insulin receptor activation (By similarity). Also acts as a regulatory component of protein phosphatase 1 (PP1) complexes (PubMed:39603239, PubMed:39603240). Component of the PNUTS-PP1 protein phosphatase complex, a PP1 complex that regulates RNA polymerase II transcription pause-release (PubMed:39603239, PubMed:39603240). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (PubMed:20516061). |
| Cellular Location | Nucleus. Chromosome. Note=Associated with chromatin; colocalizes with RNA polymerase II (Pol II) on chromatin {ECO:0000250|UniProtKB:Q8BU11} |
| Tissue Location | Expressed in liver (at protein level). |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
TOX4 (TOX high mobility group box family member 4) contains 1 HMG box DNA-binding domain and the function remains unknown.
REFERENCES
Lee, J.H., et al. J. Biol. Chem. 285(32):24466-24476(2010)
Lee, S.J., et al. Exp. Mol. Med. 41(3):189-200(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Lim, J., et al. Cell 125(4):801-814(2006)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
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