癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FIGNL1 Antibody (N-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q6PIW4 |
| Other Accession | NP_001036227.1 |
| Reactivity | Human |
| Predicted | Bovine, Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 74077 Da |
| Antigen Region | 12-40 aa |
| Gene ID | 63979 |
|---|---|
| Other Names | Fidgetin-like protein 1, 364-, FIGNL1 |
| Target/Specificity | This FIGNL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human FIGNL1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FIGNL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FIGNL1 {ECO:0000303|PubMed:23754376, ECO:0000312|HGNC:HGNC:13286} |
|---|---|
| Function | ATPase that maintains genome stability by acting as a key regulator of DNA double-strand break (DSB) repair via homologous recombination (HR) (PubMed:23754376, PubMed:37256941, PubMed:37347663, PubMed:37515771, PubMed:37556550, PubMed:38286805, PubMed:38597669, PubMed:39636933, PubMed:41166468). Regulates HR by mediating disassembly of RAD51 filaments from DNA and chromatin, thereby preventing DNA damage-independent RAD51 loading and persistent DNA accumulation of RAD51 recombinases (PubMed:37256941, PubMed:37347663, PubMed:37515771, PubMed:37556550, PubMed:38286805, PubMed:38597669, PubMed:39636933, PubMed:41166468). Also regulates HR during meiosis by mediating dissociation of DMC1 filaments from DNA (By similarity). May regulate osteoblast proliferation and differentiation (By similarity). |
| Cellular Location | Chromosome. Nucleus. Cytoplasm Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8BPY9} Note=Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
FIGNL1 may regulate osteoblast proliferation and differentiation (By similarity).
REFERENCES
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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