癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TCERG1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | O14776 |
| Other Accession | Q8CGF7, NP_006697.2, NP_001035095.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 123901 Da |
| Antigen Region | 991-1020 aa |
| Gene ID | 10915 |
|---|---|
| Other Names | Transcription elongation regulator 1, TATA box-binding protein-associated factor 2S, Transcription factor CA150, TCERG1, CA150, TAF2S |
| Target/Specificity | This TCERG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 991-1020 amino acids from the C-terminal region of human TCERG1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TCERG1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TCERG1 |
|---|---|
| Synonyms | CA150, TAF2S |
| Function | Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. |
| Cellular Location | Nucleus |
| Tissue Location | Detected in brain neurons. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.
REFERENCES
Sanchez-Alvarez, M., et al. J. Biol. Chem. 285(20):15220-15233(2010)
Koskinen, L.L., et al. Tissue Antigens 74(5):408-416(2009)
Murphy, J.M., et al. J. Mol. Biol. 393(2):409-424(2009)
Lu, M., et al. J. Mol. Biol. 393(2):397-408(2009)
Pearson, J.L., et al. J. Biol. Chem. 283(12):7949-7961(2008)
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