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TMC4 Antibody (N-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q7Z404 |
| Other Accession | NP_653287.1, NP_001138775.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 79208 Da |
| Antigen Region | 68-94 aa |
| Gene ID | 147798 |
|---|---|
| Other Names | Transmembrane channel-like protein 4, TMC4 |
| Target/Specificity | This TMC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-94 amino acids from the N-terminal region of human TMC4. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TMC4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TMC4 (HGNC:22998) |
|---|---|
| Function | Voltage-gated chloride channel involved in high-concentration salt taste sensation (PubMed:34429071, PubMed:34468713). Depolarization induced by high NaCl concentration may trigger the activation of TMC4- mediated chloride influx into taste bud cells, helping the return to resting potential (PubMed:34429071). Also allows permeation of organic anions including gluconate, but their current amplitudes at positive potentials are less than that of chloride (PubMed:34429071). Involved in pH and temperature-dependent modulation of salty taste (PubMed:34468713). |
| Cellular Location | Membrane; Multi-pass membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
TMC4 may function as ion channels, transporters or modulators of such.
REFERENCES
Kurima, K., et al. Genomics 82(3):300-308(2003)
Keresztes, G., et al. BMC Genomics 4 (1), 24 (2003) :
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