癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MSC Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | O60682 |
| Other Accession | NP_005089.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 22068 Da |
| Antigen Region | 166-194 aa |
| Gene ID | 9242 |
|---|---|
| Other Names | Musculin, Activated B-cell factor 1, ABF-1, Class A basic helix-loop-helix protein 22, bHLHa22, MSC, ABF1, BHLHA22 |
| Target/Specificity | This MSC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-194 amino acids from the C-terminal region of human MSC. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MSC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MSC |
|---|---|
| Synonyms | ABF1, BHLHA22 |
| Function | Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation. |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in lymphoid tissues, B-cell lines and activated B-cells |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq].
REFERENCES
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Ushmorov, A., et al. Leukemia 22(10):1942-1944(2008)
Knight, J.C., et al. Nat. Genet. 36(4):394-399(2004)
Wong, J., et al. DNA Cell Biol. 20(8):465-471(2001)
Robb, L., et al. Genomics 57(2):318-319(1999)
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