癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SERTAD2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q14140 |
| Other Accession | Q9JJG5, NP_055570.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 33897 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 9792 |
|---|---|
| Other Names | SERTA domain-containing protein 2, Transcriptional regulator interacting with the PHD-bromodomain 2, TRIP-Br2, SERTAD2, KIAA0127 |
| Target/Specificity | This SERTAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SERTAD2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SERTAD2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SERTAD2 |
|---|---|
| Synonyms | KIAA0127, TRIPBR2 |
| Function | Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism. |
| Cellular Location | Nucleus. Cytoplasm. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome |
| Tissue Location | Expressed in adipose tissue. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SERTAD2 acts at E2F-responsive promoters to integrate signals provided by PHD-and/or bromodomain-containing transcription factors (By similarity).
REFERENCES
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Cheong, J.K., et al. J Transl Med 7, 8 (2009) :
Cheong, J.K., et al. J. Biol. Chem. 283(17):11661-11676(2008)
Watanabe-Fukunaga, R., et al. Genes Cells 10(8):851-860(2005)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
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