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DHRS11 Antibody (Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q6UWP2 |
| Other Accession | NP_077284.2 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Canine, Rabbit, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28308 Da |
| Antigen Region | 115-142 aa |
| Gene ID | 79154 |
|---|---|
| Other Names | Dehydrogenase/reductase SDR family member 11, 1---, DHRS11 |
| Target/Specificity | This DHRS11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-142 amino acids from the Central region of human DHRS11. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DHRS11 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DHRS11 |
|---|---|
| Synonyms | SDR24C1 {ECO:0000303|PubMed:19027726} |
| Function | Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta- hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3beta-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids (PubMed:26920053). May contribute to the metabolism of adrenal-derived androgen precursors. Reduces 11-keto-4-androstene-3,17-dione (11KA4) and 11-keto-5alpha-androstane-3,17-dione (11K-Adione) into potent androgens 11-ketotestosterone (11KT) and 11-ketodihydrotestosterone (11KDHT), respectively (PubMed:31926269). May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones (PubMed:26920053). |
| Cellular Location | Secreted. |
| Tissue Location | Isoform 1: Ubiquitously expressed, with highest levels in testis, small intestine, colon, kidney, brain and heart Isoform 3: Expressed in brain, heart and skeletal muscle |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The function of this protein remains unknown.
REFERENCES
Persson, B., et al. Chem. Biol. Interact. 178 (1-3), 94-98 (2009) :
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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