癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ECSCR Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q19T08 |
| Other Accession | NP_001071161.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Bovine, Canine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 21295 Da |
| Antigen Region | 137-165 aa |
| Gene ID | 641700 |
|---|---|
| Other Names | Endothelial cell-specific chemotaxis regulator, Apoptosis regulator through modulating IAP expression, ARIA, Endothelial cell-specific molecule 2, ECSCR, ECSM2 |
| Target/Specificity | This ECSCR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-165 amino acids from the C-terminal region of human ECSCR. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ECSCR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ECSCR |
|---|---|
| Synonyms | ECSM2 |
| Function | Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cytoplasm |
| Tissue Location | Highest expression in endothelial cells. Also detected in vascular smooth muscle, macrophages, lymphocytes, and mast cells. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it may be involved in cell shape changes and EGF-induced cell migration. This gene could play a role in angiogenesis-related diseases.
REFERENCES
Ikeda, K., et al. Proc. Natl. Acad. Sci. U.S.A. 106(20):8227-8232(2009)
Ma, F., et al. Genes Cells 14(3):281-293(2009)
Graubert, T.A., et al. PLoS ONE 4 (2), E4583 (2009) :
Armstrong, L.J., et al. Arterioscler. Thromb. Vasc. Biol. 28(9):1640-1646(2008)
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
