癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GNMT Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q14749 |
| Other Accession | Q29513, Q29555, NP_061833.1 |
| Reactivity | Human |
| Predicted | Pig, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 32742 Da |
| Antigen Region | 78-106 aa |
| Gene ID | 27232 |
|---|---|
| Other Names | Glycine N-methyltransferase, GNMT |
| Target/Specificity | This GNMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-106 amino acids from the Central region of human GNMT. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GNMT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GNMT (HGNC:4415) |
|---|---|
| Function | Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate. Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L- homocysteine. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P13255}. |
| Tissue Location | Expressed only in liver, pancreas, and prostate. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia).
REFERENCES
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Lee, C.M., et al. Gene 443 (1-2), 151-157 (2009) :
Boyles, A.L., et al. Genet. Epidemiol. 33(3):247-255(2009)
Yen, C.H., et al. Toxicol. Appl. Pharmacol. 235(3):296-304(2009)
Franke, B., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 85(3):216-226(2009)
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