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>   首页   >   产品   >   一抗   >   细胞生物学   >   MS4A3 Antibody (Center)   

MS4A3 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - MS4A3 Antibody (Center) AP18066c
    MS4A3 Antibody (Center) (Cat. #AP18066c) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MS4A3 antibody detected the MS4A3 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q96HJ5
Other Accession NP_001026836.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 22933 Da
Antigen Region 97-123 aa
Additional Information
Gene ID 932
Other Names Membrane-spanning 4-domains subfamily A member 3, CD20 antigen-like protein, Hematopoietic-specific transmembrane protein 4, HTm4, MS4A3, CD20L, HTM4
Target/Specificity This MS4A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-123 amino acids from the Central region of human MS4A3.
Dilution WB~~1:1000
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMS4A3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MS4A3
Synonyms CD20L, HTM4
Function Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP).
Cellular Location Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Located in the perinuclear area
Tissue Location Expressed specifically in hematopoietic cells and tissues
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described.

REFERENCES

Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Chinami, M., et al. J. Biol. Chem. 280(17):17235-17242(2005)
Donato, J.L., et al. J. Clin. Invest. 109(1):51-58(2002)

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