癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MOG Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q16653 |
| Other Accession | Q9BGS7, NP_001008229.1 |
| Reactivity | Human |
| Predicted | Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28193 Da |
| Antigen Region | 82-109 aa |
| Gene ID | 4340 |
|---|---|
| Other Names | Myelin-oligodendrocyte glycoprotein, MOG |
| Target/Specificity | This MOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-109 amino acids from the Central region of human MOG. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MOG Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MOG |
|---|---|
| Function | Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. |
| Cellular Location | [Isoform 1]: Cell membrane; Multi- pass membrane protein [Isoform 2]: Cell membrane; Single- pass type I membrane protein [Isoform 4]: Cell membrane; Single- pass type I membrane protein [Isoform 7]: Cell membrane; Single- pass type I membrane protein [Isoform 9]: Cell membrane; Single- pass type I membrane protein |
| Tissue Location | Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Boyle, L.H., et al. J. Neurochem. 102(6):1853-1862(2007)
Allamargot, C., et al. J. Neurochem. 101(2):298-312(2007)
Delarasse, C., et al. J. Neurochem. 98(6):1707-1717(2006)
Ballenthin, P.A., et al. J. Neurosci. Res. 46(2):271-281(1996)
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