癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KLF15 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UIH9 |
| Other Accession | Q9EPW2, NP_054798.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 43992 Da |
| Antigen Region | 372-398 aa |
| Gene ID | 28999 |
|---|---|
| Other Names | Krueppel-like factor 15, Kidney-enriched krueppel-like factor, KLF15, KKLF |
| Target/Specificity | This KLF15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 372-398 amino acids from the C-terminal region of human KLF15. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KLF15 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KLF15 |
|---|---|
| Synonyms | KKLF |
| Function | Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation. |
| Cellular Location | Nucleus |
| Tissue Location | Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
KLF15 is a transcriptional activator. Binds to the GA element of the CLCNKA promoter.
REFERENCES
Yamamoto, K., et al. Biochem. Biophys. Res. Commun. 400(1):175-180(2010)
Haldar, S.M., et al. Sci Transl Med 2 (26), 26RA26 (2010) :
Li, J., et al. BMC Genet. 11, 12 (2010) :
Du, X., et al. J. Clin. Endocrinol. Metab. 94(7):2594-2601(2009)
Wang, B., et al. J. Mol. Cell. Cardiol. 45(2):193-197(2008)
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