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PCMTD1 Antibody (N-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q96MG8 |
| Other Accession | P59913, Q5ZMR3, A2VDP2, NP_443169.2 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Chicken, Rat, Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40675 Da |
| Antigen Region | 19-48 aa |
| Gene ID | 115294 |
|---|---|
| Other Names | Protein-L-isoaspartate O-methyltransferase domain-containing protein 1, PCMTD1 |
| Target/Specificity | This PCMTD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-48 amino acids from the N-terminal region of human PCMTD1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PCMTD1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PCMTD1 (HGNC:30483) |
|---|---|
| Function | Substrate recognition component of an ECS (Elongin BC-CUL5- SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:35486881). Specifically binds to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but does not display methyltransferase activity (PubMed:35486881). May provide an alternate maintenance pathway for modified proteins by acting as a damage-specific E3 ubiquitin ligase adaptor protein (PubMed:35486881). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P22061}. Membrane; Lipid-anchor |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PCMTD1 belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
REFERENCES
Rose, J. Phd, et al. Mol. Med. (2010) In press :
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