癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KCNK12 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9HB15 |
| Other Accession | NP_071338.1 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 46889 Da |
| Antigen Region | 335-364 aa |
| Gene ID | 56660 |
|---|---|
| Other Names | Potassium channel subfamily K member 12, Tandem pore domain halothane-inhibited potassium channel 2, THIK-2, KCNK12 |
| Target/Specificity | This KCNK12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 335-364 amino acids from the C-terminal region of human KCNK12. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KCNK12 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCNK12 {ECO:0000303|PubMed:24163367, ECO:0000312|HGNC:HGNC:6274} |
|---|---|
| Function | K(+) channel subunit that may homo- and heterodimerize to form functional channels with distinct regulatory and gating properties. Can heterodimerize with KCNK13 subunit to conduct K(+) outward rectifying currents at the plasma membrane. The homodimers are mainly retained in the endoplasmic reticulum compartment and may be targeted to the cell surface upon phosphorylation or other activation signals yet to be elucidated. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity.
REFERENCES
Birlea, S.A., et al. J. Invest. Dermatol. 130(3):798-803(2010)
Nyholt, D.R., et al. Hum. Mol. Genet. 17(21):3318-3331(2008)
Theilig, F., et al. Cell. Physiol. Biochem. 21 (1-3), 63-74 (2008) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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