癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PLLP Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y342 |
| Other Accession | P47987, Q9DCU2, NP_057077.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 19987 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 51090 |
|---|---|
| Other Names | Plasmolipin, Plasma membrane proteolipid, PLLP, PMLP, TM4SF11 |
| Target/Specificity | This PLLP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PLLP. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PLLP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLLP (HGNC:18553) |
|---|---|
| Synonyms | PMLP, TM4SF11 |
| Function | Main component of the myelin sheath that plays an important role in myelin membrane biogenesis and myelination (PubMed:26002055). Plays an essential function in apical endocytosis. Regulates epithelial development through the regulation of apical endocytosis (By similarity). Part of the intracellular machinery that mediates basolateral-to-apical transport of ICAM-1, an essential adhesion receptor in epithelial cells, from the subapical compartment in hepatic epithelial cells (PubMed:34999972). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Myelin membrane; Multi-pass membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:P47987}; Multi-pass membrane protein. Golgi apparatus. Note=In polarized cells, localized predominantly in the apical membrane (By similarity). Located in lipid raft (By similarity). Recycled between the plasma membrane and the Golgi complex (PubMed:26002055). PLLP is continuously recirculating in the cell (PubMed:26002055). {ECO:0000250|UniProtKB:A3KQ86, ECO:0000250|UniProtKB:P47987, ECO:0000269|PubMed:26002055} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PLLP appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity).
REFERENCES
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Hamacher, M., et al. Mamm. Genome 12(12):933-937(2001)
Fischer, I., et al. J. Biol. Chem. 269(40):24912-24919(1994)
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