癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PLEKHA8 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q96JA3 |
| Other Accession | O95397, NP_116028.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 58261 Da |
| Antigen Region | 456-482 aa |
| Gene ID | 84725 |
|---|---|
| Other Names | Pleckstrin homology domain-containing family A member 8, PH domain-containing family A member 8, Phosphatidylinositol-four-phosphate adapter protein 2, FAPP-2, Phosphoinositol 4-phosphate adapter protein 2, hFAPP2, Serologically defined breast cancer antigen NY-BR-86, PLEKHA8, FAPP2 |
| Target/Specificity | This PLEKHA8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 456-482 amino acids from the C-terminal region of human PLEKHA8. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PLEKHA8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PLEKHA8 (HGNC:30037) |
|---|---|
| Function | Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane, playing a pivotal role in the synthesis of complex glycosphingolipids; binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for this GlcCer transfer ability (PubMed:15107860, PubMed:16103222, PubMed:17687330). Also functions as a cargo transport protein required for apical transport from the Golgi complex, including transport of AQP2 from the TGN to sites of AQP2 phosphorylation. Additionally required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation (By similarity). |
| Cellular Location | Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Note=Binds through its PH domain to PtdIns(4)P and ARF1, and subsequently localizes to TGN exit sites |
| Tissue Location | Expressed in kidney cell lines. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PLEKHA8 is involved in TGN-to-plasma membrane transport and in the formation of post-Golgi constitutive carriers. May play a role in ensuring the coordination of the budding and the fission reactions.
REFERENCES
Tsao, D.A., et al. DNA Cell Biol. 29(6):285-293(2010)
Cao, X., et al. Proc. Natl. Acad. Sci. U.S.A. 106(50):21121-21125(2009)
Tritz, R., et al. Biochem. Biophys. Res. Commun. 383(2):167-171(2009)
Yamaji, T., et al. IUBMB Life 60(8):511-518(2008)
D'Angelo, G., et al. Nature 449(7158):62-67(2007)
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