癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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PAFAH1B2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P68402 |
| Other Accession | O35264, Q61206, P68401, NP_002563.1 |
| Reactivity | Human |
| Predicted | Bovine, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 25569 Da |
| Antigen Region | 61-89 aa |
| Gene ID | 5049 |
|---|---|
| Other Names | Platelet-activating factor acetylhydrolase IB subunit beta, PAF acetylhydrolase 30 kDa subunit, PAF-AH 30 kDa subunit, PAF-AH subunit beta, PAFAH subunit beta, PAFAH1B2, PAFAHB |
| Target/Specificity | This PAFAH1B2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-89 amino acids from the Central region of human PAFAH1B2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PAFAH1B2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PAFAH1B2 (HGNC:8575) |
|---|---|
| Synonyms | PAFAHB |
| Function | Alpha2 catalytic subunit of the cytosolic type I platelet- activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3- phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2- acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity). May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (By similarity). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Ubiquitous.. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
REFERENCES
Ding, C., et al. J. Cell. Sci. 122 (PT 16), 2820-2827 (2009) :
Scott, B.T., et al. Prostaglandins Other Lipid Mediat. 85 (3-4), 69-80 (2008) :
Hasstedt, S.J., et al. Thromb. Haemost. 98(3):587-592(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Sheffield, P.J., et al. Protein Eng. 14(7):513-519(2001)
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