癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PADI6 Antibody (N-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q6TGC4 |
| Other Accession | NP_997304.3 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 77727 Da |
| Antigen Region | 196-223 aa |
| Gene ID | 353238 |
|---|---|
| Other Names | Protein-arginine deiminase type-6, Peptidyl arginine deiminase-like protein, Peptidylarginine deiminase VI, hPADVI, Protein-arginine deiminase type VI, PADI6 |
| Target/Specificity | This PADI6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-223 amino acids from the N-terminal region of human PADI6. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PADI6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PADI6 {ECO:0000303|PubMed:15087120, ECO:0000312|HGNC:HGNC:20449} |
|---|---|
| Function | Structural constituent of cytoplasmic lattices, which plays a key role in early embryonic development (PubMed:37922900, PubMed:41772195). Cytoplasmic lattices consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos: they are required to store maternal proteins critical for embryonic development, such as ribosomal proteins, cytoskeletal tubulins and proteins controlling epigenetic reprogramming of the preimplantation embryo, in a poised but restrained state, regulating their availability for early embryonic development (PubMed:37922900, PubMed:41772195). Cytoplasmic lattices also tightly control ubiquitination during the oocyte-to- embryo transition by trapping E3 ubiquitin-protein ligase UHRF1 in a compact autoinhibited conformation and maintaining SCF ubiquitin ligase complexes inactive (PubMed:41772195). PADI6 oligomers acts as an essential structural scaffolding element of cytoplasmic lattices (By similarity). In contrast to other members of the family, does not show protein-arginine deiminase activity due to its inability to bind Ca(2+) (PubMed:38656308, PubMed:39286527). |
| Cellular Location | Cytoplasm. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:Q8K3V4}. Nucleus {ECO:0000250|UniProtKB:Q8K3V4}. Note=Core component of cytoplasmic lattices in oocytes (PubMed:37922900). Also nuclear (By similarity) {ECO:0000250|UniProtKB:Q8K3V4, ECO:0000269|PubMed:37922900} |
| Tissue Location | Highly expressed in oocytes and weakly expressed in other somatic tissues. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Peptidylarginine deiminases (PADs, EC 3.5.3.15), including PADI6, make up a family of posttranslational protein modification enzymes that convert arginine residues to citrulline residues in the presence of calcium ions.
REFERENCES
Stacey, S.N., et al. Nat. Genet. 40(11):1313-1318(2008)
Chavanas, S., et al. Gene 330, 19-27 (2004) :
Zhang, J., et al. Acta Biochim. Pol. 51(4):1051-1058(2004)
Vossenaar, E.R., et al. Bioessays 25(11):1106-1118(2003)
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