癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
OSBPL10 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q9BXB5 |
| Other Accession | NP_001167531.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Bovine, Canine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 83970 Da |
| Antigen Region | 669-695 aa |
| Gene ID | 114884 |
|---|---|
| Other Names | Oxysterol-binding protein-related protein 10, ORP-10, OSBP-related protein 10, OSBPL10, ORP10, OSBP9 |
| Target/Specificity | This OSBPL10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 669-695 amino acids from the C-terminal region of human OSBPL10. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OSBPL10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | OSBPL10 (HGNC:16395) |
|---|---|
| Synonyms | ORP10, OSBP9 |
| Function | Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable) (PubMed:23934110). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Interacts with OSBPL9 to function as lipid transfer proteins (PubMed:36853333). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero- 3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2- diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:36853333). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). |
| Cellular Location | Cytoplasm, cytoskeleton. Late endosome membrane. Golgi apparatus, trans-Golgi network membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane. Note=Associates with microtubules Localizes at the Golgi-late endosome interface (PubMed:22906437) |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Multiple transcript variants encoding different isoforms have been found for this gene.
REFERENCES
Koriyama, H., et al. J. Atheroscler. Thromb. 17(10):1054-1062(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Koriyama, H., et al. Hypertens. Res. 33(5):511-514(2010)
Perttila, J., et al. J. Mol. Med. 87(8):825-835(2009)
Ma, J., et al. Atherosclerosis 191(1):63-72(2007)
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