癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TTC35 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q15006 |
| Other Accession | B0BNG0, Q9CRD2, Q5E993, Q8AVU9, Q6INS3, NP_055488.1 |
| Reactivity | Human, Mouse |
| Predicted | Xenopus, Bovine, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 34834 Da |
| Antigen Region | 65-91 aa |
| Gene ID | 9694 |
|---|---|
| Other Names | ER membrane protein complex subunit 2, Tetratricopeptide repeat protein 35, TPR repeat protein 35, EMC2, KIAA0103, TTC35 |
| Target/Specificity | This TTC35 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-91 amino acids from the Central region of human TTC35. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TTC35 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EMC2 (HGNC:28963) |
|---|---|
| Function | Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176, PubMed:33964204). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N- terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). |
| Cellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side Note=May also localize to the nuclear envelope {ECO:0000250|UniProtKB:Q9CRD2} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
TTC35 is also known as TPR repeat protein 35. TPR domains consist of a variable number of degenerate tandem 34 amino acid repeats. TPR domains have been suggested to have a variety of functions in proteins in various subcellular compartments and appear to function as targeting domains, mediating specific protein-protein interactions.
REFERENCES
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Dreger, M., et al. Proc. Natl. Acad. Sci. U.S.A. 98(21):11943-11948(2001)
Hoja, M.R., et al. Exp. Cell Res. 259(1):239-246(2000)
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