癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
AGTRAP Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q6RW13 |
| Other Accession | NP_001035284.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 17419 Da |
| Antigen Region | 133-159 aa |
| Gene ID | 57085 |
|---|---|
| Other Names | Type-1 angiotensin II receptor-associated protein, AT1 receptor-associated protein, AGTRAP, ATRAP |
| Target/Specificity | This AGTRAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-159 amino acids from the C-terminal region of human AGTRAP. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AGTRAP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AGTRAP |
|---|---|
| Synonyms | ATRAP |
| Function | Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Also induces a decrease in cell proliferation and angiotensin II- stimulated transcriptional activity. |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles |
| Tissue Location | Ubiquitous but more abundant in kidney, heart, pancreas and thyroid. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Godin, C.M., et al. Mol. Pharmacol. 77(3):388-395(2010)
Rabbitts, J.A., et al. J. Physiol. (Lond.) 587 (PT 22), 5441-5449 (2009) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Newton-Cheh, C., et al. Nat. Genet. 41(6):666-676(2009)
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