癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FBXL19 Antibody (C-term)
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 2
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q6PCT2 |
| Other Accession | Q6PB97, NP_001093254.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit Ig |
| Calculated MW | 75707 Da |
| Gene ID | 54620 |
|---|---|
| Other Names | F-box/LRR-repeat protein 19, F-box and leucine-rich repeat protein 19, FBXL19, FBL19 |
| Target/Specificity | This FBXL19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 543-570 amino acids from the C-terminal region of human FBXL19. |
| Dilution | WB~~1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FBXL19 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FBXL19 |
|---|---|
| Synonyms | FBL19 |
| Function | Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. |
|
Author : Wei J1,Dong S1,2,Yao K1,Martinez MFYM1,Fleisher PR1,Zhao Y1,Ma H2,Zhao J1. FASEB J. 2018 Mar 9:fj201701069R. doi: 10.1096/fj.201701069R. [Epub ahead of print] |
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Author : Zhao J1, Mialki RK, Wei J, Coon TA, Zou C, Chen BB, Mallampalli RK, Zhao Y. FASEB J. 2013 Jul;27(7):2611-9. doi: 10.1096/fj.12-223099. Epub 2013 Mar 19. |
23512198 |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Members of the F-box protein family, such as FBXL19, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].
REFERENCES
Martin, J., et al. Nature 432(7020):988-994(2004)
Katoh, M., et al. Int. J. Mol. Med. 14(6):1109-1114(2004)
Jin, J., et al. Genes Dev. 18(21):2573-2580(2004)
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