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>   首页   >   产品   >   一抗   >   细胞生物学   >   FBXL19 Antibody (C-term)   

FBXL19 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - FBXL19 Antibody (C-term) AP18447b
    Anti-FBXL19 Antibody (C-term) at 1:2000 dilution + A549 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 76 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q6PCT2
Other Accession Q6PB97, NP_001093254.2
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 75707 Da
Antigen Region 543-570 aa
Additional Information
Gene ID 54620
Other Names F-box/LRR-repeat protein 19, F-box and leucine-rich repeat protein 19, FBXL19, FBL19
Target/Specificity This FBXL19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 543-570 amino acids from the C-terminal region of human FBXL19.
Dilution WB~~1:2000
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFBXL19 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXL19
Synonyms FBL19
Function Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays a role in different processes including cell migration, cell proliferation or cytoskeletal reorganization (PubMed:24684802, PubMed:29522376). Mediates RHOA ubiquitination and degradation in a ERK2-dependent manner (PubMed:23871831). Induces RAC1 and RAC3 degradation by the proteasome system and thereby regulates TGFB1-induced E-cadherin down-regulation and cell migration (PubMed:23512198, PubMed:24684802). Also mediates ubiquitination and degradation of IL-33-induced receptor IL1RL1 and subsequently blocks IL-33-mediated apoptosis (By similarity). Within the nucleus, binds to DNA containing unmethylated cytidine-phosphate- guanosine (CpG) dinucleotides (PubMed:29276034). Recruits CDK-mediator to chromatin and targets CDK8 to promoters of silent developmental genes leading to induction of these genes during cell differentiation. In addition, plays a critical role in the recruitment of RNF20 to histone H2B leading to H2B mono-ubiquitination (By similarity).
Cellular Location Cytoplasm. Nucleus
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Members of the F-box protein family, such as FBXL19, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].

REFERENCES

Martin, J., et al. Nature 432(7020):988-994(2004)
Katoh, M., et al. Int. J. Mol. Med. 14(6):1109-1114(2004)
Jin, J., et al. Genes Dev. 18(21):2573-2580(2004)

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