癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MPPE1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q53F39 |
| Other Accession | Q9GMS6, NP_075563.3 |
| Reactivity | Human |
| Predicted | Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 45141 Da |
| Antigen Region | 261-289 aa |
| Gene ID | 65258 |
|---|---|
| Other Names | Metallophosphoesterase 1, 31--, Post-GPI attachment to proteins factor 5, MPPE1, PGAP5 |
| Target/Specificity | This MPPE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-289 amino acids from the C-terminal region of human MPPE1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MPPE1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MPPE1 (HGNC:15988) |
|---|---|
| Function | Metallophosphoesterase that catalyzes the removal of a side- chain ethanolamine-phosphate (EtNP) from the second mannose of the GPI- anchor protein intermediate (PubMed:19837036, PubMed:29374258). Participates in the glycan remodeling steps of GPI-anchor maturation to allow an efficient transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi (PubMed:19837036, PubMed:29374258). |
| Cellular Location | Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Note=Also localizes to endoplasmic reticulum exit site. |
| Tissue Location | Expressed in brain.. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.
REFERENCES
Lohoff, F.W., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (3), 830-836 (2010) :
Fujita, M., et al. Cell 139(2):352-365(2009)
Yosifova, A., et al. J Affect Disord 117 (1-2), 87-97 (2009) :
Fortna, A., et al. PLoS Biol. 2 (7), E207 (2004) :
Vuoristo, J.T., et al. Cytogenet. Cell Genet. 95 (1-2), 60-63 (2001) :
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