癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SYCP2 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BX26 |
| Other Accession | NP_055073.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 175639 Da |
| Antigen Region | 1345-1372 aa |
| Gene ID | 10388 |
|---|---|
| Other Names | Synaptonemal complex protein 2, SCP-2, Synaptonemal complex lateral element protein, hsSCP2, SYCP2, SCP2 |
| Target/Specificity | This SYCP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1345-1372 amino acids from the C-terminal region of human SYCP2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SYCP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SYCP2 |
|---|---|
| Synonyms | SCP2 |
| Function | Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9CUU3}. Chromosome {ECO:0000250|UniProtKB:Q9CUU3}. Note=In axial/lateral elements of the tripartite segments of synaptonemal complexes {ECO:0000250|UniProtKB:Q9CUU3} |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The synaptonemal complex is a proteinaceous structure that links homologous chromosomes during the prophase of meiosis. The protein encoded by this gene is a major component of the synaptonemal complex and may bind DNA at scaffold attachment regions. The encoded protein requires synaptonemal complex protein 3, but not 1, for inclusion in the synaptonemal complex. [provided by RefSeq].
REFERENCES
Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Schalk, J.A., et al. Mamm. Genome 10(6):642-644(1999)
Offenberg, H.H., et al. Nucleic Acids Res. 26(11):2572-2579(1998)
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