癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TFDP3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q5H9I0 |
| Other Accession | NP_057605.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 44967 Da |
| Antigen Region | 82-108 aa |
| Gene ID | 51270 |
|---|---|
| Other Names | Transcription factor Dp family member 3, Cancer/testis antigen 30, CT30, Hepatocellular carcinoma-associated antigen 661, TFDP3, DP4, HCA661 |
| Target/Specificity | This TFDP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-108 amino acids from the N-terminal region of human TFDP3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TFDP3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TFDP3 |
|---|---|
| Synonyms | DP4, HCA661 |
| Function | Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase. |
| Cellular Location | Nucleus. Cytoplasm. Note=Translocates to the nucleus on heterodimerization with E2F family members |
| Tissue Location | Predominantly expressed in testis. Low level of expression in pancreas. Highly expressed in ovarian and colon cancer cell lines. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the DP family of transcription factors. These factors heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. This protein functions as a negative regulator and inhibits the DNA binding and transcriptional activities of E2F factors.
REFERENCES
Tian, C., et al. Biochem. Biophys. Res. Commun. 361(1):20-25(2007)
Qiao, H., et al. J. Biol. Chem. 282(1):454-466(2007)
Milton, A., et al. Oncogene 25(22):3212-3218(2006)
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