癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
APOBEC3D Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q96AK3 |
| Other Accession | NP_689639.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 46598 Da |
| Antigen Region | 46-72 aa |
| Gene ID | 140564 |
|---|---|
| Other Names | DNA dC->dU-editing enzyme APOBEC-3D, A3D, 354-, APOBEC3D |
| Target/Specificity | This APOBEC3D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of human APOBEC3D. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | APOBEC3D Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | APOBEC3D (HGNC:17354) |
|---|---|
| Function | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent mechanisms (PubMed:16920826, PubMed:20062055, PubMed:21835787). Exhibits antiviral activity against HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single- strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA (PubMed:16920826). The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Also inhibits the mobility of LTR and non-LTR retrotransposons (PubMed:27428332). |
| Cellular Location | Cytoplasm. Cytoplasm, P-body |
| Tissue Location | Expressed in lymphoid organs. Also detected in non- lymphoid tissues including lung. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Unknown. Unable to reduce HIV-1 infectivity in vitro.
REFERENCES
Zhang, W., et al. PLoS ONE 3 (12), E3963 (2008) :
Dang, Y., et al. J. Virol. 80(21):10522-10533(2006)
Stenglein, M.D., et al. J. Biol. Chem. 281(25):16837-16841(2006)
Conticello, S.G., et al. Mol. Biol. Evol. 22(2):367-377(2005)
Harris, R.S., et al. Nat. Rev. Immunol. 4(11):868-877(2004)
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¥ 1,250.00
Cat# AP18763a
