癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MLC1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q15049 |
| Other Accession | Q60HE7, NP_055981.1 |
| Reactivity | Human |
| Predicted | Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 41141 Da |
| Antigen Region | 337-366 aa |
| Gene ID | 23209 |
|---|---|
| Other Names | Membrane protein MLC1, MLC1, KIAA0027, WKL1 |
| Target/Specificity | This MLC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 337-366 amino acids from the C-terminal region of human MLC1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MLC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MLC1 (HGNC:17082) |
|---|---|
| Function | Transmembrane protein mainly expressed in brain astrocytes that may play a role in transport across the blood-brain and brain- cerebrospinal fluid barriers (PubMed:22328087). Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx (PubMed:22328087). May function as regulatory protein of membrane protein complexes such as ion channels (Probable). |
| Cellular Location | Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Endoplasmic reticulum |
| Tissue Location | Expressed in the brain, with highest levels found in the amygdala, nucleus caudatus, thalamus and hippocampus |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The function of this gene product is unknown; however, homology to other proteins suggests that it may be an integral membrane transporter. Mutations in this gene have been associated with megalencephalic leukoencephalopathy with subcortical cysts, an autosomal recessive neurological disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.
REFERENCES
Yis, U., et al. Turk. J. Pediatr. 52(2):179-183(2010)
Lanciotti, A., et al. Neurobiol. Dis. 37(3):581-595(2010)
Shukla, P., et al. Prenat. Diagn. 28(4):357-359(2008)
Ambrosini, E., et al. Mol. Cell. Neurosci. 37(3):480-493(2008)
Selch, S., et al. Biol. Psychiatry 61(10):1211-1214(2007)
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