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CALHM3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q86XJ0 |
| Other Accession | NP_001123214.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38496 Da |
| Antigen Region | 68-97 aa |
| Gene ID | 119395 |
|---|---|
| Other Names | Calcium homeostasis modulator protein 3, Protein FAM26A, CALHM3, FAM26A |
| Target/Specificity | This CALHM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-97 amino acids from the N-terminal region of human CALHM3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CALHM3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CALHM3 (HGNC:23458) |
|---|---|
| Synonyms | FAM26A |
| Function | Pore-forming subunit of gustatory voltage-gated ion channels required for sensory perception of sweet, bitter and umami tastes. With CALHM1 forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to membrane depolarization and low extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of small ions including Ca(2+), Na(+), K(+) and Cl(-), as well as larger ions such as ATP(4-). |
| Cellular Location | Basolateral cell membrane {ECO:0000250|UniProtKB:J3QMI4}; Multi-pass membrane protein |
| Tissue Location | Specifically expressed in circumvallate taste bud cells. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The specific function of CALHM3 remains unknown. There are two different isoforms generated by alternative splicing.
REFERENCES
Shibata, N., et al. J. Alzheimers Dis. 20(2):417-421(2010)
Dreses-Werringloer, U., et al. Cell 133(7):1149-1161(2008)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Deloukas, P., et al. Nature 429(6990):375-381(2004)
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