癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TBX4 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P57082 |
| Other Accession | Q9W7C2, Q5I2P1, P70326, Q99593, Q9PWE8, P70325, NP_060958.2 |
| Reactivity | Human, Mouse |
| Predicted | Mouse, Rat, Chicken, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 60204 Da |
| Antigen Region | 103-129 aa |
| Gene ID | 9496 |
|---|---|
| Other Names | T-box transcription factor TBX4, T-box protein 4, TBX4 |
| Target/Specificity | This TBX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-129 amino acids from the N-terminal region of human TBX4. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TBX4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TBX4 |
|---|---|
| Function | Transcriptional regulator that has an essential role in the organogenesis of lungs, pelvis, and hindlimbs. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity.
REFERENCES
Kim, J.J., et al. J. Hum. Genet. 55(1):27-31(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
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