癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Mouse Stk38 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q91VJ4 |
| Other Accession | Q15208, A2VDV2, NP_598876.1 |
| Reactivity | Mouse |
| Predicted | Bovine, Human, Rat, Canine, Rabbit, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54174 Da |
| Antigen Region | 429-458 aa |
| Gene ID | 106504 |
|---|---|
| Other Names | Serine/threonine-protein kinase 38, NDR1 protein kinase, Nuclear Dbf2-related kinase 1, Stk38 {ECO:0000312|EMBL:AAH096581} |
| Target/Specificity | This Mouse Stk38 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 429-458 amino acids from the C-terminal region of mouse Stk38. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Stk38 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Stk38 {ECO:0000312|EMBL:AAH09658.1} |
|---|---|
| Function | Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed:21730291). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity). Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q15208}. Cytoplasm {ECO:0000250|UniProtKB:Q15208}. Chromosome {ECO:0000250|UniProtKB:Q15208}. Note=Localizes to DNA double-strand breaks in response to DNA damage. {ECO:0000250|UniProtKB:Q15208} |
| Tissue Location | Expressed at high levels in spleen, lung, thymus, brain and fat tissue. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its nonphosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity).
REFERENCES
Cornils, H., et al. Sci Signal 3 (126), RA47 (2010) :
Stegert, M.R., et al. J. Biol. Chem. 279(22):23806-23812(2004)
Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)
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Cat# AP19186B
