癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SEPT12 Antibody (Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8IYM1 |
| Other Accession | NP_001147930.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40748 Da |
| Antigen Region | 218-244 aa |
| Gene ID | 124404 |
|---|---|
| Other Names | Septin-12, SEPT12 |
| Target/Specificity | This SEPT12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-244 amino acids from the Central region of human SEPT12. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SEPT12 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SEPTIN12 (HGNC:26348) |
|---|---|
| Synonyms | SEPT12 |
| Function | Filament-forming cytoskeletal GTPase (By similarity). Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta- tubulins (PubMed:24213608). Facilitates the formation of Septin filament structures with SEPTIN7, SEPTIN6, SEPTIN2 and SEPTIN4 at the sperm annulus (PubMed:25588830, PubMed:28346465). Correct formation of the annulus is required for development of normal structural morphology and motility of the sperm during steps 13 to 16 of spermiogenesis (PubMed:25588830). Essential component of the LMNB1/SUN5/SEPT12 bridge that connects the sperm proximal centriole to the implantation fossa, the bridge functions to prevent detachment of the proximal centriole from the posterior nucleus during steps 13 to 16 of spermiogenesis (PubMed:38870534). Required for PLCZ1 localization at the sperm acrosome during spermiogenesis (By similarity). May also play a role in the initiation of calcium oscillations in embryos (By similarity). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Nucleus Cell projection, cilium, flagellum Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:A0A2R8VJU7}. Note=At interphase, forms a filamentous structure in the cytoplasm. During anaphase, translocates to the central spindle region and to the midbody during cytokinesis Colocalized with SPAG4 at the nuclear periphery in round spermatids During sperm head formation in elongating spermatids, expressed at the acrosome, perinuclear mantle of the manchette structure and the sperm neck (By similarity). Expressed at mitochondrial materials in elongating spermatids (By similarity). Expressed in mature sperm at the annulus, neck and tail (By similarity). Expressed at the midpiece in ejaculated mature sperm (By similarity) {ECO:0000250|UniProtKB:A0A2R8VJU7, ECO:0000269|PubMed:18047794, ECO:0000269|PubMed:20801438, ECO:0000269|PubMed:22275165, ECO:0000269|PubMed:25775403} |
| Tissue Location | Widely expressed. Expressed in lymph node. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Septins, such as SEPT12, are conserved GTP-binding proteins that function as dynamic, regulatable scaffolds for the recruitment of other proteins. They are involved in membrane dynamics, vesicle trafficking, apoptosis, and cytoskeleton remodeling, as well as infection, neurodegeneration, and neoplasia (Hall et al., 2005 [PubMed 15915442]).
REFERENCES
Lin, Y.H., et al. Am. J. Pathol. 174(5):1857-1868(2009)
Ding, X., et al. Mol. Cells 25(3):385-389(2008)
Ding, X., et al. J. Biochem. Mol. Biol. 40(6):973-978(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Hall, P.A., et al. J. Pathol. 206(3):269-278(2005)
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