癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CCNDBP1 Antibody(N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | O95273 |
| Other Accession | Q4R809, NP_036274.3 |
| Reactivity | Human |
| Predicted | Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40262 Da |
| Antigen Region | 21-49 aa |
| Gene ID | 23582 |
|---|---|
| Other Names | Cyclin-D1-binding protein 1, Grap2 and cyclin-D-interacting protein, Human homolog of Maid, CCNDBP1, DIP1, GCIP, HHM |
| Target/Specificity | This CCNDBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-49 amino acids from the N-terminal region of human CCNDBP1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CCNDBP1 Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCNDBP1 |
|---|---|
| Synonyms | DIP1, GCIP, HHM |
| Function | May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription. |
| Cellular Location | Cytoplasm. Nucleus. |
| Tissue Location | Ubiquitously expressed. Expression is down- regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq].
REFERENCES
Lee, I., et al. Cancer Res. 70(11):4357-4365(2010)
Seto, A., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65 (PT 1), 21-24 (2009) :
Ikushima, H., et al. EMBO J. 27(22):2955-2965(2008)
Chen, W.C., et al. Histopathology 53(5):554-560(2008)
Chang, T.W., et al. Oncogene 27(3):332-338(2008)
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