癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Mouse Dyrk1a Antibody(C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q61214 |
| Other Accession | NP_001106860.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 85494 Da |
| Antigen Region | 718-745 aa |
| Gene ID | 13548 |
|---|---|
| Other Names | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dual specificity YAK1-related kinase, MP86, Protein kinase minibrain homolog, MNBH, Dyrk1a, Dyrk |
| Target/Specificity | This Mouse Dyrk1a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 718-745 amino acids from the C-terminal region of mouse Dyrk1a. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Dyrk1a Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Dyrk1a |
|---|---|
| Synonyms | Dyrk |
| Function | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities (PubMed:18938227, PubMed:20123978). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3 (By similarity). Plays an important role in double-strand breaks (DSBs) repair following DNA damage (By similarity). Mechanistically, phosphorylates RNF169 and increases its ability to block accumulation of TP53BP1 at the DSB sites thereby promoting homologous recombination repair (HRR) (By similarity). Also acts as a positive regulator of transcription by acting as a CTD kinase that mediates phosphorylation of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (By similarity). May play a role in a signaling pathway regulating nuclear functions of cell proliferation (By similarity). Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Has pro- survival function and negatively regulates the apoptotic process (PubMed:20167603). Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1 (PubMed:20167603). This in turn inhibits p53/TP53 activity and apoptosis (PubMed:20167603). Phosphorylates SEPTIN4, SEPTIN5 and SF3B1 at 'Thr-434' (PubMed:18938227). |
| Cellular Location | Nucleus speckle. |
| Tissue Location | Detected in brain (at protein level) (PubMed:22998443). Expressed in a variety of embryonic and adult tissues (PubMed:8975710). Expressed abundantly in neurons of the brain, spinal cord, and retina in developing embryos (PubMed:8975710) Expressed in the entorhinal, temporal and visual cortices and the hippocampus of the brain where is colocalizes with SEPTIN4 (PubMed:18938227). Expressed and extensively colocalizes with SEPTIN4 in apical dendrites of pyramidal cells (PubMed:18938227). Also expressed in Purkinje cells in the cerebellum in postnatal day 1 and adult mice (PubMed:18938227). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Dyrk1a may play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.
REFERENCES
Park, J., et al. J. Biol. Chem. 285(41):31895-31906(2010)
Guo, X., et al. J. Biol. Chem. 285(17):13223-13232(2010)
Kurabayashi, N., et al. Mol. Cell. Biol. 30(7):1757-1768(2010)
Lee, Y., et al. J. Biol. Chem. 284(48):33343-33351(2009)
Noll, C., et al. PLoS ONE 4 (10), E7540 (2009) :
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