癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ZNF410 Antibody(C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q86VK4 |
| Other Accession | NP_067011.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52113 Da |
| Antigen Region | 448-477 aa |
| Gene ID | 57862 |
|---|---|
| Other Names | Zinc finger protein 410, Another partner for ARF 1, Zinc finger protein APA-1, ZNF410, APA1 |
| Target/Specificity | This ZNF410 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 448-477 amino acids from the C-terminal region of human ZNF410. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZNF410 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZNF410 {ECO:0000303|PubMed:33301730, ECO:0000312|HGNC:HGNC:20144} |
|---|---|
| Function | Transcription factor that binds to the sequence motif 5'- CATCCCATAATA-3', and is specifically required to silence expression of fetal hemoglobin in adult erythroid cells (PubMed:33301730, PubMed:33859416). Prevents expression of fetal hemoglobin genes HBG1 and HBG2 through CHD4: acts as a direct transcriptional activator of CHD4, a central component of the NuRD complex that represses transcription of fetal hemoglobin genes HBG1 and HBG2 in erythroid cells (PubMed:33301730, PubMed:33859416). May also activate transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence (PubMed:12370286). May activate transcription of the gap junction gene GJC1, perhaps in response to increasing glucose (PubMed:30078215). However, recent studies suggest that ZNF410 is dedicated to regulate expression of a single gene: CHD4 (PubMed:33301730, PubMed:33859416). |
| Cellular Location | Nucleus. Chromosome. Note=Directly binds to the sequence motif 5'-CATCCCATAATA-3'. |
| Tissue Location | Widely expressed.. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.
REFERENCES
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Hubner, R.A., et al. Int. J. Cancer 123(3):586-593(2008)
Benanti, J.A., et al. Mol. Cell. Biol. 22(21):7385-7397(2002)
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¥ 1,250.00
Cat# AP19435b
