癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LONP1 Antibody(Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P36776 |
| Other Accession | Q924S5, Q8CGK3, Q59HJ6, NP_004784.2 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Bovine, Mouse, Rat, Canine, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 106489 Da |
| Antigen Region | 389-418 aa |
| Gene ID | 9361 |
|---|---|
| Other Names | Lon protease homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03120}, 3421- {ECO:0000255|HAMAP-Rule:MF_03120}, LONHs, Lon protease-like protein {ECO:0000255|HAMAP-Rule:MF_03120}, LONP {ECO:0000255|HAMAP-Rule:MF_03120}, Mitochondrial ATP-dependent protease Lon {ECO:0000255|HAMAP-Rule:MF_03120}, Serine protease 15 {ECO:0000255|HAMAP-Rule:MF_03120}, LONP1 {ECO:0000255|HAMAP-Rule:MF_03120}, PRSS15 |
| Target/Specificity | This LONP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-418 amino acids from the Central region of human LONP1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LONP1 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | LONP1 {ECO:0000255|HAMAP-Rule:MF_03120, ECO:0000312|HGNC:HGNC:9479} |
|---|---|
| Function | ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix (PubMed:12198491, PubMed:15870080, PubMed:17579211, PubMed:37327776, PubMed:8248235, PubMed:35870450, PubMed:38688959). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, DELE1, helicase Twinkle (TWNK) and the large ribosomal subunit protein MRPL32/bL32m (PubMed:17579211, PubMed:28377575, PubMed:37327776). MRPL32/bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575). In addtion to its protease activity, has also an ATP-dependent protein folding chaperone activity and functions in mitochondrial protein folding (PubMed:33431889). Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome (PubMed:17420247). Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner (PubMed:17420247). May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:14739292, PubMed:17420247). |
| Cellular Location | Mitochondrion matrix {ECO:0000255|HAMAP- Rule:MF_03120, ECO:0000269|PubMed:7961901} |
| Tissue Location | Duodenum, heart, lung and liver, but not thymus. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a mitochondrial matrix protein in the Lon family of ATP-dependent proteases. A similar E. coli protein regulates gene expression by targeting specific regulatory proteins for degradation. This protein binds a specific sequence in the light and heavy chain promoters of the mitochondrial genome which are involved in regulation of DNA replication and transcription.
REFERENCES
Hansen, J., et al. Neuroscience 153(2):474-482(2008)
Chen, S.H., et al. Nucleic Acids Res. 36(4):1273-1287(2008)
Bogenhagen, D.F., et al. J. Biol. Chem. 283(6):3665-3675(2008)
Bayot, A., et al. Biochimie 90(2):260-269(2008)
Xue, X., et al. Nan Fang Yi Ke Da Xue Xue Bao 27(6):870-874(2007)
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