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>   首页   >   产品   >   一抗   >   代谢   >   CLIC6 Antibody(C-term)   

CLIC6 Antibody(C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CLIC6 Antibody(C-term) AP19553b
    CLIC6 Antibody (C-term) (Cat. #AP19553b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CLIC6 antibody detected the CLIC6 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q96NY7
Other Accession Q9N2G5, NP_444507.1
Reactivity Human
Predicted Rabbit
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 73012 Da
Antigen Region 676-704 aa
Additional Information
Gene ID 54102
Other Names Chloride intracellular channel protein 6, Parchorin, CLIC6, CLIC1L
Target/Specificity This CLIC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 676-704 amino acids from the C-terminal region of human CLIC6.
Dilution WB~~1:1000
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCLIC6 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLIC6 {ECO:0000303|PubMed:37838179, ECO:0000312|HGNC:HGNC:2065}
Function In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent chloride-selective channels. The channel opens upon membrane depolarization at positive voltages and closes at negative membrane voltages (PubMed:37838179). May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity).
Cellular Location Cytoplasm. Cell membrane; Single-pass membrane protein Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity)
Tissue Location Expressed in brain, placenta, pancreas, liver, lung, heart, kidney, liver, spleen, soleus muscle, and brown fat
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined.

REFERENCES

Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :
Friedli, M., et al. Gene 320, 31-40 (2003) :
Strippoli, P., et al. Mamm. Genome 13(8):456-462(2002)
Scanlan, M.J., et al. Cancer Immun. 1, 4 (2001) :

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