癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
STARD13 Antibody(Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 7
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y3M8 |
| Other Accession | NP_443083.1, NP_821074.1, NP_821075.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 124967 Da |
| Antigen Region | 544-573 aa |
| Gene ID | 90627 |
|---|---|
| Other Names | StAR-related lipid transfer protein 13, 46H232, Deleted in liver cancer 2 protein, DLC-2, Rho GTPase-activating protein, START domain-containing protein 13, StARD13, STARD13, DLC2, GT650 |
| Target/Specificity | This STARD13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 544-573 amino acids from the Central region of human STARD13. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | STARD13 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STARD13 |
|---|---|
| Synonyms | DLC2, GT650 |
| Function | GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. |
| Cellular Location | Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet |
| Tissue Location | Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein that contains a sterile alpha motif domain in the N-terminus, an ATP/GTP-binding motif, a GTPase-activating protein domain, and a STAR-related lipid transfer domain in the C-terminus. The gene is located in a region of chromosome 13 that has loss of heterozygosity in hepatic cancer. At least three alternatively spliced transcript variants have been described for this gene.
REFERENCES
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Yasuno, K., et al. Nat. Genet. 42(5):420-425(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Xiaorong, L., et al. BMC Cancer 8, 205 (2008) :
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郑禄枫
2017-11-30 10:33:27
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Species tested
人
Application tested
WB
Organization tested
乳腺癌细胞裂解液
Barcode encoding
Brief protocol
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