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为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CLSTN2 Antibody(Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H4D0 |
| Other Accession | NP_071414.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 107006 Da |
| Antigen Region | 743-770 aa |
| Gene ID | 64084 |
|---|---|
| Other Names | Calsyntenin-2, Alcadein-gamma, Alc-gamma, CLSTN2, CS2 |
| Target/Specificity | This CLSTN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 743-770 amino acids from the Central region of human CLSTN2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CLSTN2 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLSTN2 (HGNC:17448) |
|---|---|
| Synonyms | CS2 |
| Function | Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate synapse formation, and which is involved in learning and memory (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). |
| Cellular Location | Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9ER65}; Single-pass type I membrane protein. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9ER65}; Single-pass type I membrane protein. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9ER65}; Single-pass type I membrane protein. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9ER65}. Note=Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization {ECO:0000250|UniProtKB:Q9ER65} |
| Tissue Location | Restricted to the brain. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CLSTN2 may modulate calcium-mediated postsynaptic signals (By similarity).
REFERENCES
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Preuschhof, C., et al. Neuropsychologia 48(2):402-408(2010)
Zhang, H., et al. Neuropsychopharmacology 34(12):2508-2516(2009)
Henckaerts, L., et al. Clin. Gastroenterol. Hepatol. 7(9):972-980(2009)
Jacobsen, L.K., et al. Biol. Psychiatry 65(8):671-679(2009)
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