癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PRRX2 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q99811 |
| Other Accession | Q06348, NP_057391.1 |
| Reactivity | Mouse |
| Predicted | Rat, Bovine, Canine, Rabbit, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 27079 Da |
| Antigen Region | 223-250 aa |
| Gene ID | 51450 |
|---|---|
| Other Names | Paired mesoderm homeobox protein 2, Paired-related homeobox protein 2, PRX-2, PRRX2, PMX2, PRX2 |
| Target/Specificity | This PRRX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-250 amino acids from the C-terminal region of human PRRX2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PRRX2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PRRX2 |
|---|---|
| Synonyms | PMX2, PRX2 |
| Function | May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138} |
| Tissue Location | In fetal skin, highest expression found in cells of mesodermal origin within the dermal papilla of the developing hair shaft. Not detected in epidermis or dermis. In adult skin, weakly expressed within the basal layers of the epidermis. Not expressed in dermis. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.
REFERENCES
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010) :
Tokutomi, Y., et al. Biochem. Biophys. Res. Commun. 364(4):822-830(2007)
Wissmuller, S., et al. Nucleic Acids Res. 34(6):1735-1744(2006)
Gervais, C., et al. Leukemia 19(1):145-148(2005)
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