癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LGALS3BP Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P-Leica, E |
|---|---|
| Primary Accession | Q08380 |
| Other Accession | NP_005558.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 65331 Da |
| Antigen Region | 383-412 aa |
| Gene ID | 3959 |
|---|---|
| Other Names | Galectin-3-binding protein, Basement membrane autoantigen p105, Lectin galactoside-binding soluble 3-binding protein, Mac-2-binding protein, MAC2BP, Mac-2 BP, Tumor-associated antigen 90K, LGALS3BP, M2BP |
| Target/Specificity | This LGALS3BP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-412 amino acids from the Central region of human LGALS3BP. |
| Dilution | WB~~1:1000-1:2000 IHC-P-Leica~~1:100 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LGALS3BP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LGALS3BP |
|---|---|
| Synonyms | M2BP |
| Function | Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells. |
| Cellular Location | Secreted. Secreted, extracellular space, extracellular matrix |
| Tissue Location | Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1.
REFERENCES
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Srirajaskanthan, R., et al. Mol. Cell Proteomics 9(4):656-666(2010)
Zambelli, D., et al. Int. J. Cancer 126(1):41-52(2010)
Lee, J.H., et al. Pathology 41(3):229-233(2009)
Kim, S.J., et al. Acta Haematol. 120(4):211-216(2008)
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