癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GDI1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P31150 |
| Other Accession | P50398, P50396, Q8HXX7, P21856, NP_001484.1 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Bovine, Monkey, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 50583 Da |
| Antigen Region | 415-443 aa |
| Gene ID | 2664 |
|---|---|
| Other Names | Rab GDP dissociation inhibitor alpha, Rab GDI alpha, Guanosine diphosphate dissociation inhibitor 1, GDI-1, Oligophrenin-2, Protein XAP-4, GDI1, GDIL, OPHN2, RABGDIA, XAP4 |
| Target/Specificity | This GDI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 415-443 amino acids from the C-terminal region of human GDI1. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GDI1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GDI1 |
|---|---|
| Synonyms | GDIL, OPHN2, RABGDIA, XAP4 |
| Function | Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. |
| Cellular Location | Cytoplasm. Golgi apparatus, trans-Golgi network |
| Tissue Location | Brain; predominant in neural and sensory tissues. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation.
REFERENCES
Martins-de-Souza, D., et al. J Psychiatr Res 44(14):989-991(2010)
Massignan, T., et al. Mol. Cell Proteomics 9(4):611-622(2010)
Chen, Y., et al. Biochem. J. 422(2):229-235(2009)
Zhang, K.J., et al. Yi Chuan 30(5):590-594(2008)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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