癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KRT86 Antibody (Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | O43790 |
| Other Accession | Q9Z2T6, P78386, P78385, A4FUZ0, Q14533, Q148H4, A6NCN2, NP_002275.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat, Canine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 53501 Da |
| Antigen Region | 300-327 aa |
| Gene ID | 3892 |
|---|---|
| Other Names | Keratin, type II cuticular Hb6, Hair keratin K211, Keratin-86, K86, Type II hair keratin Hb6, Type-II keratin Kb26, KRT86, KRTHB6 |
| Target/Specificity | This KRT86 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-327 amino acids from the Central region of human KRT86. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KRT86 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KRT86 (HGNC:6463) |
|---|---|
| Synonyms | KRTHB6 |
| Function | Structural component of intermediate filaments in the hair shaft (PubMed:15744029, PubMed:25557232). Forms obligate heterodimers with type I hair keratins, which assemble into keratin intermediate filaments that contribute to the structural integrity and mechanical strength of the hair shaft (PubMed:15744029, PubMed:25557232). |
| Tissue Location | Expressed in the hair follicle, predominantly in the hair shaft cortex (PubMed:11445569). Synthesis begins slightly higher in the hair shaft than KRT81 and KRT83 and continues much farther up, ending in the keratogeneous zone |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix.
REFERENCES
ZHANG, S.D., et al. Eur J Dermatol 19(5):508-509(2009)
Feng, A.P., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25(2):141-144(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Schweizer, J., et al. J. Cell Biol. 174(2):169-174(2006)
Langbein, L., et al. Int. Rev. Cytol. 243, 1-78 (2005) :
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